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Abstract
Directed evolution of cytochrome P450 enzymes fine-tunes site selectivity of new-to-nature C‒H amidation for modular, sustainable and scalable preparation of enantio-enriched β-, γ- and δ-lactams.
Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis
13 February 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.
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Now Published
Site-selective enzymatic C‒H amidation for synthesis of diverse lactams [opens in a new tab]
Inha Cho, Zhi-Jun Jia, Frances H. Arnold journal article
Science , Volume 364, Issue 6440
Print publication date: May 10, 2019
Version History
Jan 03, 2020 Version
2
(Retracted)
Feb 13, 2019 Version 1
(Retracted)
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Author’s competing interest statement
Caltech has filed a provisional patent application (CIT-8187-P)