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Abstract
Directed evolution of cytochrome P450 enzymes fine-tunes site selectivity of new-to-nature C‒H amidation for modular, sustainable and scalable preparation of enantio-enriched β-, γ- and δ-lactams.
Content
Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis
Working Paper
Now Published
Site-selective enzymatic C‒H amidation for synthesis of diverse lactams [opens in a new tab] open_in_new
Inha Cho, Zhi-Jun Jia, Frances H. Arnold journal article
Science , Volume 364, Issue 6440
Print publication date: May 10, 2019
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Feb 13, 2019 Version
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The content is available under CC BY NC ND 4.0 License
CreativeCommons.org [opens in a new tab] open_in_new
DOI
Author’s competing interest statement
Caltech has filed a provisional patent application (CIT-8187-P)
Keywords
C‒H Amidation
biocatalysis strategies
Cytochrome P450s
lactam ring
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This content is an early or alternative research output and has not been
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