Working Paper
Authors
- Tomas Vojkovsky ,
- Shubham Deolka ,
- Saiyyna P. Stepanova ,
- Michael C. Roy ,
- Eugene Khaskin
Okinawa Institute of Science and Technology Graduate University
Abstract
Sulfones and sulfonamides with an α-CH bond can be easily alkylated by aliphatic alcohols to add the carbon skeleton of the alcohol via a one-step, Ru(II) catalyzed redox neutral reaction. The reaction requires a sub-stoichiometric amount of base and produces only water as a byproduct. A number of pharmaceutically relevant functional groups such as piperidine, morpholine, etc. are well tolerated under the reaction conditions to give higher value-added products in one step from widely available substrates. The reaction proceeds through a sulfone carbanion addition to an in-situ generated aldehyde formed via catalytic dehydrogenation and subsequent catalyst mediated replacement of the secondary alcohol by hydrogen.
Content

Supplementary material

SI Khaskin ChemRxiv