A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

18 December 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

Keywords

E3 Ligase
protein degradation
von Hippel Lindau
PROTAC
Caged ligand
Light Activated

Supplementary materials

Title
Description
Actions
Title
SI Kounde Caged PROTAC Chemrxiv 10 Dec 2019
Description
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