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Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

20 December 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [11C]carbon dioxide and [11C]methyl iodide into fluoride-activated silanes.

Keywords

Carbon-11
silane compound
fluoride anion
carboxylic acid chemical function
[11C]CO2 fixation-reduction
Positron Emission Tomography

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Version History

Dec 20, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.11371086.v1
D O I: 10.26434/chemrxiv.11371086.v1 [opens in a new tab]

Funding

MR/K022733/1
FP7-PEOPLE-2012-ITN 316882
WT 088641/Z/09/Z

Author’s competing interest statement

None

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