Opening up Connectivity Between Documents, Structures and Bioactivity

20 November 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


This article assesses a key aspect of data sharing that has the potential to accelerate the progress and impact of medicinal chemistry. To achieve this the community needs to increase the outward flow of experimental results locked-up in millions of published PDFs into structured open databases that explicitly capture the connectivity between structures, documents and bioactivity results.


literature connectivity
drug discovery
Chemical structures


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