Application of Amino Transaminases in a Disperse System for the Biotransformation of Hydrophobic Substrates

05 November 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting in a combination of a low polarity solvent (e.g. isooctane or MTBE), a non-ionic surfactant and a minimal amount of water. In these conditions, good conversions are achieved, often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized and stereochemically characterized.


Disperse systems
Reductive amination
stereoselective reaction

Supplementary materials

Supporting Info 30-10-19


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.