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Total Synthesis and Structural Verification of Isatindigotindoline C

29 October 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Total synthesis of the polycyclic alkaloid isatindigotindoline C is achieved in two steps using an exo-selective [3+2]-dipolar cycloaddition. The synthesis verifies the originally computationally assigned relative stereochemistry.

Keywords

Oxindole Alkaloids
Total Synthesis
Isatindigotindoline C
Dipolar Cycloadditions
Biomimetic Synthesis

Supplementary materials

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isatindigotindoline SI chemrxiv 251019
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Now Published

Total synthesis of isatindigotindoline C [opens in a new tab]
Juha H. Siitonen, Sherlin Lira, Muhammed Yousufuddin, László Kürti journal article
Organic & Biomolecular Chemistry , Volume 18, Issue 11
Online publication date: 2020

Version History

Oct 29, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.10052531.v1
D O I: 10.26434/chemrxiv.10052531.v1 [opens in a new tab]

Funding

NIH R01 GM-114609-04
NSF CAREER:SusChEM CHE-1546097
Welch Foundation C-1764

Author’s competing interest statement

N/A

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