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C–H Functionalization Approach for the Synthesis of Chiral C2 Symmetric 1,5-Cyclooctadienes Ligands

28 October 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Chiral cyclooctadiene (COD) derivatives are readily prepared by rhodium-catalyzed allylic C-H functionalization of COD. Either mono or difunctionalization of COD is possible generating the products in high yield, diastereoselectivity and enantioselectivity.

Keywords

C-H functionalization
rhodium-carbene

Supplementary materials

Title
Description
Actions
Title
SI COD V15 Submitted version
Description
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Now Published

C–H Functionalization Approach for the Synthesis of Chiral C2-Symmetric 1,5-Cyclooctadiene Ligands [opens in a new tab]
Bowen Zhang, Michael R. Hollerbach, Simon B. Blakey, Huw M. L. Davies journal article
Organic Letters , Volume 21, Issue 24
Online publication date: Dec 04, 2019

Version History

Oct 28, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.10032209.v1
D O I: 10.26434/chemrxiv.10032209.v1 [opens in a new tab]

Funding

NSF CCI Phase II Center for Selective C—H Functionalization (CHE-1700982)
NSF (CHE 1531620)
NSF (CHE 1626172)

Author’s competing interest statement

HMLD is a named inventor on a patent entitled, Dirhodium Catalyst Compositions and Synthetic Processes Related Thereto (US 8,974,428, issued March 10, 2015).

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