Synthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization

24 October 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Isoquinolines and their derivatives are present in many natural products and biologically active small molecules. Herein, we report a modified procedure for the Classical Pomeranz-Fritsch protocal, which expands the scope of 1,2-dihydroisoquinoline products.


Silyl Triflates
Lewis acid complexation
tetrahydroisoquinoline compound


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