Emergence of Light-Driven Protometabolism upon Recruitment of a Photocatalytic Cofactor by a Self-Replicator

22 October 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


This work shows how a designed co-factor can be recruited and activated by a self-replicator to do photo-redox catalysis and generate the precursors from which the self-replicator can grow. It constitutes an important step in the direction of the de-novo synthesis of life by intergrating self-replication with a protometabolism.


Systems chemistry
Dynamic combinatorial chemistry
De-novo life
Photoredox catalysis


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