Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

Angelo Frei; Maite Amado; Matthew Cooper; Mark A. T. Blaskovich

doi:10.26434/chemrxiv.9900875.v1

Inorganic Chemistry

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Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

27 September 2019, Version 1

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Abstract

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

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Now Published

Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria

Angelo Frei, Maite Amado, Matthew A. Cooper, Mark A. T. Blaskovich journal article

Chemistry – A European Journal , Volume 26, Issue 13

Online publication date: Jan 30, 2020

Version History

Oct 16, 2019 Version 2

Sep 27, 2019 Version 1

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Version 1_With Supporting Information

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.9900875.v1

Funding

Swiss National Science Foundation, P2ZHP2_177997

APP1059354

WT1104797/Z/14/Z

Author’s competing interest statement

There are no conflicts to declare.

Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

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