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Abstract
A general approach is described for the
formation of tetrahydrothiepines using donor-acceptor cyclopropanes.
Thiochalcones, functioning as sulfur-containing four-atom building blocks, were
reacted in a Lewis-acid-catalyzed formal (4+3)-cycloaddition reaction with
donor-acceptor cyclopropanes as three-atom building blocks. Under mild
conditions various tetrahydrothiepines were synthesized in good yields in a stereosepecific reaction with high functional group tolerance.
