Analytical Chemistry

Mass Spectrometry Reveals the Assembly Pathway of Encapsulated Ferritins and Highlights a Dynamic Ferroxidase Interface

Abstract

Encapsulated ferritins (EncFtn) are a recently characterised member of the ferritin superfamily. EncFtn proteins are sequestered within encapsulin nanocompartments and form a unique biological iron storage system. Here, we use native mass spectrometry and hydrogen-deuterium exchange mass spectrometry to elucidate the metal-mediated assembly pathway of EncFtn.

Content

Thumbnail image of Ross et al Assembly Pathway (ChemRxiv).pdf

Supplementary material

Thumbnail image of Ross et al Assembly Pathway SI (ChemRxiv).pdf
Ross et al Assembly Pathway SI (ChemRxiv)