An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials

10 September 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing welldefined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.


organometallic chemistry
atomically precise nanoparticles
protein-protein interactions
protein-carbohydrate interactions
cluster chemistry
boron clusters
gold chemistry


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