Catalysis

Using Alcohols As Simple H2-Equivalents for Copper-Catalysed Transfer Hydrogenations

Authors

Abstract

Catalytic transfer hydrogenations are among the most practical synthetic methods for the selective reduction of functional groups. Cheap and readily available dihydrogen (H2) equivalents are highly desirable for catalytic transfer hydrogenations, as inevitably, waste is generated by the formal H2 source. Copper hydride catalysis generally relies on stoichiometric use of waste-generating hydrosilanes. Here, we demonstrate that simple alcohols can be employed as H2 equivalents in stereoselective alkyne semihydrogenations, prototypical copper hydride-catalysed transformations.

Content

Thumbnail image of Teichert_Transfer Hydrogenation Copper_manuscript.pdf

Supplementary material

Thumbnail image of Teichert_Transfer Hydrogenation Copper_ESI.pdf
Teichert Transfer Hydrogenation Copper ESI
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Teichert Transfer Hydrogenation Copper TOC Graphic