Catalysis

Bioinformatics-Guided Discovery of Citrulline 4-Hydroxylase from GE81112 Biosynthesis and Rational Engineering of Its Substrate Specificity

Authors

Abstract

We functionally characterize a nonheme dioxygenase from GE81112 biosynthesis and identify it as a citrulline hydroxylase. A bioinformatics guided engineering was performed to alter the substrate specificity of the enzyme.

Content

Thumbnail image of GetI Manuscript Chemrxiv v2.pdf

Supplementary material

Thumbnail image of GetI SI combined FINAL.pdf
GetI SI combined FINAL