A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on gram scale.
Louis C. Morrill Cardiff University
download asset Manuscript.pdf 0.43 MB [opens in a new tab] cloud_download
pdf : 0.43 MB
download asset Supporting Information.pdf 14 MB [opens in a new tab] cloud_download
pdf : 14 MB