Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.
Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release
24 June 2019, Version 2
This content is a preprint and has not undergone peer review at the time of posting.