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Step-by-Step Real Time Monitoring of a Catalytic Amination Reaction

01 July 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The multiple reaction monitoring mode of a triple quadrupole mass spectrometer is used to examine the Buchwald-Hartwig amination reaction at 0.1% catalyst loading in real-time using sequential addition of reagents to probe the individual steps in the cycle. This is a powerful new method for probing reactions under realistic conditions.

Keywords

Buchwald-Hartwig
amination
cross-coupling
palladium
mass spectrometry
real-time analysis
multiple reaction monitoring

Supplementary materials

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Now Published

Step-by-step real time monitoring of a catalytic amination reaction [opens in a new tab]
Gilian T. Thomas, Eric Janusson, Harmen S. Zijlstra, J. Scott McIndoe journal article
Chemical Communications , Volume 55, Issue 78
Online publication date: 2019

Version History

Jul 01, 2019 Version 1

Version Notes

Preprint not yet formatted for submission

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.8345594.v1
D O I: 10.26434/chemrxiv.8345594.v1 [opens in a new tab]

Funding

NSERC Discovery

Author’s competing interest statement

No conflict of interest

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