eMap: a Web Application for Identifying and Visualizing Electron or Hole Hopping Pathways in Proteins

27 March 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


eMap is a web-based platform for identifying and visualizing electron or hole transfer pathways in proteins based on their crystal structures. The underlying model can be viewed as a coarse-grained version of the Pathways model with only through-space tunneling between electron transfer active (ETA) moieties being taken into account. ETA moieties include aromatic amino acid residue side chains and aromatic fragments of cofactors that are automatically detected, and, in addition, electron/hole residing sites that can be specified by the users. The software searches for the shortest paths connecting the user-specified electron/hole source to either all surface-exposed ETA residues or to the user-specified target. The identified pathways are ranked based on their length. The pathways are visualized in 2D as a graph, in which each node represents an ETA site, and in 3D using available protein visualization tools. Here we present the capability and user interface of eMap 1.0, which is available at https://emap.bu.edu.


Electron Transfer
Electron Tunneling
Graph Theory
Crystal Structure Analysis
Web Application

Supplementary materials

emap SI


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