Ground State Destabilization in Uracil DNA Deglycosylase (UDG): Let’s Not Forget “Tautomeric Strain” in Substrates

18 June 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


QM and QM/MM computations reveal that some enzymes, like the uracil DNA deglycosylase, may achieve ground state destabilization through substrate "tautomeric strain."


enzyme catalysis
ground state destabilization
substrate strain
Uracil DNA deglycosylase


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