Organic Chemistry

A Metal-Free Facile Construction of C(sp3) –CF3 Bond: Trifluoromethylation of Hydrazones with Togni’s Reagent under Mild Conditions

Huiying Zeng Lanzhou University


A metal-free trifluoromethylation of hydrazones with Togni’s reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen and heterocyclic compounds were tolerated. This simple and green strategy provides a practical tool to construct C(sp3) –CF3 bonds


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Supplementary material

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Supporting Information 0615