Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines

10 June 2019, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report here an original electrosynthetic method allowing the straightforward C(sp3)-H a-carbamoylation of free cyclic secondary amines. Based on a TEMPO-catalyzed indirect anodic oxidation and a multicomponent coupling, a wide variety of N-acyl alpha-carboxamides have been obtained in remarkably mild and sustainable reaction conditions.

Keywords

Electrosynthesis
Multicomponent reaction
C(sp3)-H functionalization
Carbamoylation
TEMPO
Anodic oxidation
Amines
isocyanides
Carboxylic acids

Supplementary materials

Title
Description
Actions
Title
Supporting Information 6.0
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Electrochemical TEMPO-catalyzed multicomponent C(sp3)–H α-carbamoylation of free cyclic secondary amines [opens in a new tab]
Na Pan, Johanne Ling, Ramiro Zapata, Jean-Pierre Pulicani, Laurence Grimaud, Maxime R. Vitale journal article
Green Chemistry , Volume 21, Issue 22
Online publication date: 2019

Version History

Jun 10, 2019 Version 1

Metrics

4,285
804
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
NC logo
NC
ND logo
ND
The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.8242418.v1
D O I: 10.26434/chemrxiv.8242418.v1 [opens in a new tab]

Author’s competing interest statement

no conflict of interest

Share