Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines

10 June 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report here an original electrosynthetic method allowing the straightforward C(sp3)-H a-carbamoylation of free cyclic secondary amines. Based on a TEMPO-catalyzed indirect anodic oxidation and a multicomponent coupling, a wide variety of N-acyl alpha-carboxamides have been obtained in remarkably mild and sustainable reaction conditions.

Keywords

Electrosynthesis
Multicomponent reaction
C(sp3)-H functionalization
Carbamoylation
TEMPO
Anodic oxidation
Amines
isocyanides
Carboxylic acids

Supplementary materials

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