Strong Hydrogen Bonds Are Not Shielded in Ionic Liquids

05 June 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Hydrogen bonds are arguably the most important of noncovalent interactions. The physical properties of water and the information storage in DNA depend on H-bonding, for instance. To this day, the balance between the Coulombic and covalent contributions to H-bonds is still under debate. Here, we show that H-bonded host-guest systems associate in ionic liquids, pure salts with melting point below room temperature, in which dipole-dipole electrostatic interactions should be negligible in comparison with dipole-charge interactions. Binding constants (Ka) obtained from titrations of four H-bonded host-guest systems in two organic solvents and two ionic liquids yield smaller yet comparable Kavalues in ionic liquids than in organic solvents. We also detect the association event using force spectroscopy. Our results indicate that strong H-bonds are only moderately affected by surroundings composed entirely of charges, suggesting that the balance of Coulombic to covalent forces is not tipped towards the former.


hydrogen bond
Host-guest chemistry
ionic liquids
Noncovalent Interactions

Supplementary materials

Strong Hydrogen Bonds Are Not Shielded in Ionic Liquids SI ChemRxiv


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