Surface Co-Presentation of BMP-2 and Integrin Selective Ligands at the Nanoscale Favors β1 Integrin Adhesion

03 June 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying single BMP-2 dimersare prepared by block-copolymer micellar nanolithography and azide-functionalized integrin ligands (RGD peptides or α5β1integrin peptidomimetics) are immobilized on the surrounding polyethylene glycol alkyne by click chemistry.


nanopatterning technique
integrin adhesion
Growth Factors
Click Chemistry Approach Using


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