Golden Opportunity: A Clickable Azide-Functionalized [Au25(SR)18]-Nanocluster Platform for Interfacial Surface Modifications

16 May 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Ultrasmall atomically precise monolayer-protected gold thiolate nanoclusters are an intensely researched nanomaterial framework, but there is a lack of a system that can be directly synthesized and undergo interfacial surface chemistry. We report an [Au25(SCH2CH2-p-C6H4-N3)18]- nanocluster platform with azide moieties appended onto each surface ligand. The structure of this surface reactive cluster has been confirmed by single-crystal X-ray crystallography, mass spectrometry and UV-Vis, IR and NMR spectroscopies. We show that all surface azide moieties are amenable to cluster-surface strain-promoted alkyne-azide cycloaddition (CS-SPAAC) chemistry with a strained cyclooctyne, opening this as a new platform to allow functional, post-assembly surface modifications to this very prominent nanocluster.


Gold Nanoclusters
SPAAC click reactions
X-ray structures


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