A biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions

15 April 2019, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


An indicator displacement assay (IDA) was used to probe phosphate ions in acqueous medium at neutral pH using a dinuclear cerium based complex [Ce2(HXTA)]3+. The homoleptic complex can be used to detect phosphate ions in micromolar concentrations either spectrophotometrically or with the naked-eye. To our knowledge, this is the biomimetic detection system with the highest affinity known to date for selective, naked-eye based phosphate recognition under physiological conditions.


pyrocathecol violet
indicator displacement assay


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.