Hollow Zeolite Microspheres Give Enzymes a Home: A Hybrid Heterogeneous Catalyst for Chemoenzymatic Cascade Reactions

04 March 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We propose a new strategy for the preparation of a hybrid catalyst based on the TS-1 zeolite and on glucose oxidase. The design allows to combine all the features of the zeolite with a high enzyme loading. The method is based on the aerosol-assisted self-assembly of TS-1 nanocrystals to form hollow mesoporous zeolite microspheres with tailored texture and good epoxidation activity in water. The latter spheres were subsequently loaded with various amounts of enzymes which were then cross-linked to secure their entrapment. Thus, the hollow spheres were used both as catalysts and as vessels for the enzyme. The chemo-enzymatic formation of epoxides by tandem catalysis is demonstrated.


Chemo-Enzymatic Synthesis
glucose oxidase
Hybrid Materials

Supplementary materials

Smeets Debecker TS-1 and glucose oxidase cascade - preprint - ESI


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