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Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

Working Paper

Jian Li ,
Xiao Zhang ,
Hans Renata The Scripps Research Institute

Abstract

We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.

Content

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Supplementary material

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ODD SI 040319 FINAL

Now Published

Asymmetric Chemoenzymatic Synthesis of (−)‐Podophyllotoxin and Related Aryltetralin Lignans

Jian Li, Xiao Zhang, Hans Renata

Angewandte Chemie International Edition, Volume 58, Issue 34

Online publication date: Jul 17, 2019

Version History

Apr 04, 2019 Version 1

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The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv.7946729.v1

Funding

GM128895

Author’s competing interest statement

No conflict of interest

Keywords

Podophyllotoxin

Total synthesis

Biocatalysis

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Publication

This content is an early or alternative research output and has not been peer-reviewed at the time of posting.

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ISSN 2573-2293 (Online)