Catalysis

Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

Authors

Abstract

We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.

Content

Thumbnail image of ODD Chemrxiv.pdf

Supplementary material

Thumbnail image of ODD SI 040319 FINAL.pdf
ODD SI 040319 FINAL