Chemical Engineering and Industrial Chemistry

An Integrated Console for Capsule-Based, Fully Automated Organic Synthesis


The current laboratory-based practice of organic synthesis renders automation difficult, suffers from safety and environmental hazards, and hampers the implementation of artificial intelligence guided drug discovery. Using a combination of innovative reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules in a fully automated fashion. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two of the most desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.


Thumbnail image of Synple ChemRxiv 22.03.2019.pdf

Supplementary material

Thumbnail image of SI full - Synple ChemRxiv_21032019.pdf
SI full - Synple ChemRxiv 21032019
Thumbnail image of Setup of automated capsule-based console.mp4
Setup of automated capsule-based console