Self-Assembled Nanostructure Library from Monodisperse Sequence-Defined Oligo(phosphodiester)s

25 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Natural biopolymers achieve information storage, molecular recognition and catalysis efficiently through sequence-control. To be able to mimic such properties, self-assembly studies of artificial sequence-defined oligomers is of great interest. In this paper, we show the use of hydrophilic, lipophilic, aromatic and fluorophilic monomers to synthesize a large library of truly monodisperse sequence-defined block co-oligo(phosphodiester)s. Automated and accurate control over the sequence allowed to rationally study the degree of polymerisation, blocks ratio, chemical composition and orthogonal supramolecular interactions influence on self-assembly. Interestingly, our studies revealed remarkable morphological changes (spheres to nanosheets) caused by very small differences between polymers, e.g., polymers differing by a single monomer unit. Inverting block sequence in multi-block copolymers also caused a dramatic increase in micelle size. Conventional polymerization does not allow the exploration of these subtle variations in polymer sequence or composition. Therefore, fast synthesis and purification of a variety of oligomers with slightly different sequences allows studying the supramolecular chemistry of precision oligomers in a systematic way. It paves the way to the rational design of functional sequence-defined polymers.


Sequence-Controlled Polymers
Block Copolymers

Supplementary materials

Supporting Information


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.