Regio- and Diastereoselective Intermolecular [2+2] Cycloadditions Photocatalyzed by Quantum Dots

14 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Here we show that colloidal quantum dots serve as visible-light chromophores, photocatalysts, and resuable scaffolds for homo- and hetero-intermolecular [2+2] photocycloadditions of 4-vinylbenzoic acid derivatives, with >90% tunable regioselectivity and up to 98% diastereoselectivity for the previously minor syn-cyclobutane products, including the syn-heda-to-tail cyclobutane, which has never been produced as the major product of a photochemical reaction.


photocatalysis systems
quantum dots
Cycloaddition Reactivity
cyclobutane ring
templated reactions

Supplementary materials

Jiang SI


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