Mechanochemistry Enables Targeted Synthesis of Mixed-Metal Microporous Metal-Organic Frameworks Using Pre-Assembled Precursors

07 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Ball milling mechanochemistry enables enables targeted, rapid synthesis of mixed-metal metal-organic frameworks (MOFs) with controllable stoichiometric composition. Specifically, the use of ball milling enabled the use of pre-assembled coordination polymers of zinc, magnesium, nickel(II) and cobalt(II) as precursors in an innovative mechanochemical strategy for the deliberate assembly of mixed-metal MOF-74 materials comprised of pairs of transition of main group metals in a pre-determinmed 1:1 stoichiometric ratio, including ZnMg-, ZnCo, ZnCu, MgZn-, MgCo-, MgCa-, NiZn-,NiMg-, NiCo-, CoZn-, CoMg- and CoCu-MOF-74. While this is the first example of target-oriented MOF synthesis using mechanochemistry, it also provides an entry to controlling the stoichiometric composition of mixed-metal frameworks.


metal-organic frameworks
mixed-metal materials
green chemistry
X-ray diffraction
microporous materials
solvent-free chemistry
transition metals
main group elements

Supplementary materials

SI ChemRxiv


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