A DNA-Encoded Macrocycle Library that Resembles Natural Macrocycles

06 February 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein we perform a seven-step chemical synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of custom synthesis of bifunctional building block libraries. Our work outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed.

Keywords

Macrocycles
DNA Encoded Libraries

Supplementary materials

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Supporting Info DNA-Encoded Macrocycle Library ChemRxiv
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