Nanohoop Rotaxanes via Active Template Syntheses and Their Potential in Sensing Applications

28 January 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The synthesis of nanohoop rotaxanes via two different active template strategies is reported. By preparing triazole-embedded rotaxanes, the observation of metal binding events in both organic and aqueous conditions are readily observed via dramatic changes in nanohoop emission. Inspired by this result, we then describe the design and synthesis of a new type of "self-destructing" nanohoop rotaxane that, in the presence of an analyte, releases a quenched nanohoop macrocycle resulting in a bright fluorescence response. More broadly, this work highlights the conceptual advantages of combining compact π-rich macrocyclic frameworks with mechanical bonds formed via active-template syntheses.


active template
mechanical bond


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