Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly

18 October 2018, Version 3
This content is a preprint and has not undergone peer review at the time of posting.


Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.


KDEL Receptor Mediated Endocytosis
Biological activity


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