Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow

24 October 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A general strategy for the synthesis of 3,4-dioxygenated quinolin-2-one natural products is reported. The key
step is a regioselective insertion of arynes into unsymmetric imides in flow.


Flow chemistry
Natural Products
Total Synthesis


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