Intermolecular Heck Coupling with Hindered Alkenes Driven by Carboxylate Directivity

15 October 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Pd(0)-catalyzed, non-chain-walking Mizoroki-Heck reactions exhibit poor reactivity with polysubsti- tuted, unbiased alkenes. Intermolecular reactions with simple, all-carbon tetrasubstituted alkenes are unprecedented. Here we report that pendant carboxylic acids, combined with bulky monophospine ligands on palladium, can direct the arylation of tri- and tetrasubstituted olefins. Quaternary carbons are established at high Fsp3 attached-ring junctures and the carboxylate directing group can be removed after coupling. Carboxylate directivity prevents over-arylation of the new, less hindered alkene, which can be diversified in subsequent reactions.


Directing Groups
beta-hydride elimination


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