Optoregulated Drug Release from an Engineered Living Hydrogel

14 September 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A living hydrogel has been developed with metabolically and optogenetically engineered E. coli encapsulated within an agarose-based hydrogel matrix to produce and release deoxyviolacein in response to blue light irradiation. Localized, tunable and prolonged drug release have been demonstrated.


E. coli
Metabolic Engineering
Controlled Release


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.