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Reversing Conventional Site-Selectivity in C(sp3)-H Bond Activation

05 September 2018, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Distal C(sp3)–H bonds of aliphatic alcohols are preferentially activated over proximate C(sp3)–H bonds through a combination of directing group design and ligand acceleration.

Keywords

C-H activation
aliphatic alcohol
site-selectivity switch

Supplementary materials

Title
Description
Actions
Title
SMReverseSiteSelectivityYu
Description
Actions

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Now Published

Reversing conventional site-selectivity in C(sp3)–H bond activation [opens in a new tab]
Guoqin Xia, Jiang Weng, Luoyan Liu, Pritha Verma, Ziqi Li, Jin-Quan Yu journal article
Nature Chemistry , Volume 11, Issue 6
Online publication date: Apr 15, 2019

Version History

Sep 05, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.7040291.v1
D O I: 10.26434/chemrxiv.7040291.v1 [opens in a new tab]

Author’s competing interest statement

we declare no conflicts of interests.

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