Organic Chemistry

Diverse Cyclopentenes via Enantioselective Cu-Catalyzed Desymmetrization

Reece Jacques University of Oxford
,

Abstract

A highly regio-, diastereo- and enantioselective Cu-catalyzed desymmetrization of diverse meso-bisphosphates with alkyl zirconium nucleophiles has been developed. The reaction allows access to a broad range of functionalized cyclopentenes with up to three contiguous stereogenic centers, including quaternary centers and spirocyclic ring systems.

Content

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Supplementary material

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Cyclopentene Desymmetrization SI