Optoregulated Protein Release from an Engineered Living Material

24 July 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


An engineered living material for light-regulated protein release is realized by combining optogenetics, bacterial protein secretion and hydrogels. Hydrogel-immobilized bacteria are optogenetically programmed to express and secrete a fluorescent protein in response to light irradiation. Using light, tunability and localized confinement of protein expression along with dosing of protein release are demonstrated.


Living materials
Bacterial Hydrogel
Protein Release


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