Biological and Medicinal Chemistry

Optoregulated Protein Release from an Engineered Living Material



An engineered living material for light-regulated protein release is realized by combining optogenetics, bacterial protein secretion and hydrogels. Hydrogel-immobilized bacteria are optogenetically programmed to express and secrete a fluorescent protein in response to light irradiation. Using light, tunability and localized confinement of protein expression along with dosing of protein release are demonstrated.


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