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Palladium(II)-Catalyzed γ-Selective Hydroarylation of Alkenyl Carbonyl Compounds with Arylboronic Acids

17 April 2018, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene.

Keywords

Directing Groups
Alkene functionalization
Hydroarylation Reactions
Synthetic Methods
regioselectivity

Supplementary materials

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Now Published

Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids [opens in a new tab]
Rei Matsuura, Tanner C. Jankins, David E. Hill, Kin S. Yang, Gary M. Gallego, Shouliang Yang, Mingying He, Fen Wang, Rohan P. Marsters, Indrawan McAlpine, Keary M. Engle journal article
Chemical Science , Volume 9, Issue 44
Online publication date: 2018

Version History

Apr 17, 2018 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.6148124.v1
D O I: 10.26434/chemrxiv.6148124.v1 [opens in a new tab]

Funding

1R35GM125052

Author’s competing interest statement

No conflict of interest to declare.

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