Palladium(II)-Catalyzed γ-Selective Hydroarylation of Alkenyl Carbonyl Compounds with Arylboronic Acids

Rei Matsuura; Tanner Jankins; Kin Yang; Gary Gallego; Shouliang Yang; Mingying He; Fen Wang; Rohan Marsters; Indrawan McAlpine; Keary Engle

doi:10.26434/chemrxiv.6148124.v1

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Palladium(II)-Catalyzed γ-Selective Hydroarylation of Alkenyl Carbonyl Compounds with Arylboronic Acids

Working Paper

Rei Matsuura ,
Tanner Jankins ,
Kin Yang ,
Gary Gallego ,
Shouliang Yang ,
Mingying He ,
Fen Wang ,
Rohan Marsters ,
Indrawan McAlpine ,
Keary Engle The Scripps Research Institute

Abstract

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene.

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Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

Rei Matsuura, Tanner C. Jankins, David E. Hill, Kin S. Yang, Gary M. Gallego, Shouliang Yang, Mingying He, Fen Wang, Rohan P. Marsters, Indrawan McAlpine, Keary M. Engle

Chemical Science , Volume 9, Issue 44

Online publication date: 2018