On the Dimorphism and the Pressure-Temperature State Diagram of Racemic m-Nisoldipine, a Dihydropyridine Calcium Ion Antagonist

06 April 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The pressure-temperature phase diagram of the dimorphism of racemic m-nisoldipine is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192 K, which indicates that these polymorphs are enantiotropically related and that form A is stable at room temperature. Nevertheless, the phase relationship turns to be monotropic when pressures become greater than about 100 MPa, which indicates that form B becomes the sole stable phase.


Racemic m-nisoldipine
crystalline polymorphism
topological P-T diagram
thermodynamic stability


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