Catalysis

Catalytic, Enantioselective Synthesis of Allenyl Boronates

Abstract

A method to achieve enantioselective 1,4-hydroboration of terminal enynes to access allenyl boronates under CuH catalysis is described. The reaction typically proceeds in a highly stereoselective manner and tolerates an array of synthetically useful functional groups. The utility of the enantioenriched allenyl boronate products is demonstrated through several representative downstream derivatizations.

Content

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Supplementary material

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Supporting Information
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4b