Catalytic, Enantioselective Synthesis of Allenyl Boronates

14 February 2018, Version 1
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

A method to achieve enantioselective 1,4-hydroboration of terminal enynes to access allenyl boronates under CuH catalysis is described. The reaction typically proceeds in a highly stereoselective manner and tolerates an array of synthetically useful functional groups. The utility of the enantioenriched allenyl boronate products is demonstrated through several representative downstream derivatizations.

Keywords

Allenes
Asymmetric Catalysis
Enynes
Hydroboration
Homogeneous Catalysis

Supplementary materials

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