Unrestrictive protein modification localization and quality control for open search of mass spectra

18 January 2018, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We have developed PTMiner, a first software tool for automated, confident filtering, localization and annotation of protein post-translational modifications identified by open (mass-tolerant) search of large tandem mass spectrometry datasets. The performance of the software was validated on carefully designed simulation data.


post-translational modifications
false discovery rates
unrestrictive modification localization
open search


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