pH-mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

05 December 2017, Version 1

Abstract

At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant concentration range, i.e. from micromolar to nanomolar at molar ratios of up to 30:1.

Content

Supplementary materials

Serrano et al QIRSN38 ESI ChemRxiv v1

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