A Ball Milling Enabled Cross-Electrophile Coupling

14 June 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The nickel-catalyzed cross-electrophile coupling of aryl (pseudo)halides and alkyl (pseudo)halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C–C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive set-ups, in reaction times of 2 hours. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the catalytic cycle of nickel. A library of 28 cross- electrophile coupled building blocks has been constructed to exemplify this technique.


cross-electrophile coupling
zinc metal
Nickel catalysis
ball milling

Supplementary materials

Cross Electrophile Supporting Information


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