Organic Chemistry

A Ball Milling Enabled Cross-Electrophile Coupling

Authors

Abstract

The nickel-catalyzed cross-electrophile coupling of aryl (pseudo)halides and alkyl (pseudo)halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C–C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive set-ups, in reaction times of 2 hours. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the catalytic cycle of nickel. A library of 28 cross- electrophile coupled building blocks has been constructed to exemplify this technique.

Content

Thumbnail image of Cross Electrophile Manuscript.pdf

Supplementary material

Thumbnail image of Cross Electrophile Supporting Information.pdf
Cross Electrophile Supporting Information