Nicholas Riley

Postdoctoral Fellow
Stanford, CA
In my graduate training in the Prof. Josh Coon's lab, I developed new mass spectrometry instrumentation and methodology to leverage ion-ion reactions and other modes of tandem mass spectrometry for proteomic analyses. I specifically applied these technologies to large-scale characterization of intact proteins and post-translational modifications, namely glycosylation and phosphorylation. As a postdoctoral researcher in Prof. Carolyn Bertozzi's group, I am investigating new ways to study and modify cell surfaces in cancer cells to understand tumor progression. Through chemical tools to label and engineer mucin-type proteins and sialosides in the cancer glycocalyx (the collection of cell surface glycoconjugates), I aim to understand the role of glycosylation in cancer metastasis and how to develop new therapeutic strategies based on this knowledge.