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Zinc Protoporphyrin–trimethylamine-N-Oxide Complex Involves Cholesterol Oxidation Causing Atherosclerosis

preprint
submitted on 24.06.2020 and posted on 26.06.2020 by Navendu Paul,, Rudra Sarkar, Sabyasachi Sarkar
Trimethylamine-N-oxide (TMAO) has recently been correlated as biomarker for atherosclerosis. In a model study, we show that the free TMAO when bonded with zincprotoporphyrin IX, [ZnPP], in blood plasma as [TMAOZnPP] is transported to the lipid site is the reacting species to oxidize cholesterol causing atherosclerosis

Funding

SERB-DST (EMR/2015/001328), New. Delhi

History

Email Address of Submitting Author

abya@iitk.ac.in

Institution

Ramakrishna Mission Vidyamandira, Belurmath-711202 West Bengal

Country

India

ORCID For Submitting Author

0000-0002-8954-4375

Declaration of Conflict of Interest

There are no conflicts to declare

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